Aminobenzoic acids and derivatives
Medchemexpress LLC 2-Amino-5-fluoropyridine | 21717-96-4 | MFCD01861120 | 99.9% | 112.11 | C5H5FN2 | 25g
2-Amino-5-fluoropyridine is a drug intermediate for synthesis of various active compounds
AdipoGen Talabostat mesylate
Chemical. CAS 150080-09-4. Formula C9H19BN2O3 . CH4O3S. MW 310.2. Talabostat is an orally bioavailable non-selective inhibitor of dipeptidyl-peptidases DPPs, including DPP-4, DPP-7/QPP, DPP-8, DPP-9, fibroblast activation protein FAP and prolyl endopeptidase PREP PEP IC50s = >4, 310, 4, 11, 560 and 390 nM, respectively. Talabostat induces powerful anti-tumor immune responses in cancer models. Talabostat is a NLRP1 and caspase recruitment domain family member 8 CARD8 inflammasome activator. Talabostat triggers an immunostimulatory form of programmed cell death known as pyroptosis selectively in monocytes and macrophages. DPP8/9 inhibition by Talabostat activates the inflammasome sensor protein Nlrp1b, which in turn activates pro-caspase-1 to mediate pyroptosis, suggesting that DPP8/9 serve as an intracellular checkpoint to restrain Nlrp1b and the innate immune system.
Apexbio Technology LLC Obatoclax mesylate (GX15-070) 803712-79-0 10mM (in 1mL DMSO)
Obatoclax mesylate (GX15-070) is a small-molecule inhibitor targeting multiple anti-apoptotic proteins within the BCL-2 family including BCL-2 BCL-XL MCL-1 A1 and BCL-B It functions by binding to their BH3-binding grooves thereby disrupting interactions with pro-apoptotic proteins such as Bak and Bim promoting apoptotic processes Obatoclax mesylate induces apoptosis in cultured acute myeloid leukemia (AML) cells and primary AML patient samples evidencing inhibitory effects on clonogenic growth with IC50 values below 200 nmol/L In preclinical research applications this compound shows activity in xenograft models of solid tumors and multiple myeloma providing a relevant chemical tool for oncology research focused on apoptotic mechanisms and hematologic malignancies
Medchemexpress LLC Pipecolinic acid | 535-75-1 | MFCD00064347 | 99.9% | 129.16 | C6H11NO2 | 100g
Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway In addition Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3]
Selleck Chemical LLC Astragaloside A S2415-50mg
Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus which has been widely used for the treatment of cardiovascular diseases
Chem-Impex International, Inc. 2-Amino-6-methylbenzoic acid | MFCD00007809 | 5G
2-Amino-6-methylbenzoic acid, MFCD00007809, 5G
Chem-Impex International, Inc. 2-Amino-6-methylbenzoic acid | MFCD00007809 | 1G
2-Amino-6-methylbenzoic acid, MFCD00007809, 1G
STA PHARMACEUTICAL US LLC 2-(Fmoc-amino)-4-chlorobenzoic acid | 50 g | CAS 332121-92-3 | MDL MFCD02682157
2-(Fmoc-amino)-4-chlorobenzoic acid is a Amino Acid reagent (Subcategory: Unusual AA) sold by WuXi TIDES. Offered in 50 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 332121-92-3
- MDL: MFCD02682157
- InChIKey: BIPQSYSWHUYDEA-UHFFFAOYSA-N
- Molecular Weight: 393.823
- Molecular Formula: C22H16ClNO4
- Purity: ≥95%
- Container Type: 250 mL HDPE
- Pack Size: 50 g
- Net Weight: 50 g
- Gross Weight: 89.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-chlorobenzoic acid
- SMILES: ClC1=CC(NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=C(C=C1)C(O)=O
